Effects of Chemical Enhancers on the Release of Glipizide through matrix Patch
نویسنده
چکیده
The aim of the present investigation was to investigate the effect of chemical enhancers on the release of glipizide through transdermal matrix patch using different ratio of different chemical enhancers. L-menthol, oleic acid and n-octanol were tried over the glipizide matrix patch. The used concentrations of L-menthol and oleic acid were 1%, 1.5% and 2.0% and concentration of n-octanol was 1%. To prepare the transdermal matrix-patch, ethyl cellulose (EC) and poly vinyl pyrrolidone (PVP) were used as polymers. Di-Butyl phthalate (DBP) was used as plasticizer at 30 % concentration of the total polymer weight. Then these transdermal patches were evaluated for drug release. Drug release rates were different for different formulation. Here, addition of chemical enhancers has decreased the percentage release.
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